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Review
. 2009 Apr;46(1):7-11.
doi: 10.1016/j.cyto.2008.12.024. Epub 2009 Feb 23.

IL-17F: regulation, signaling and function in inflammation

Seon Hee Chang  1 , Chen Dong
Affiliations
Review

IL-17F: regulation, signaling and function in inflammation

Seon Hee Chang et al. Cytokine. 2009 Apr.

Abstract

The IL-17 cytokine family is composed of six members. IL-17F, discovered in 2001, recently has drawn increasing attention due to its greatest similarity to IL-17, a widely recognized inflammatory cytokine. The genes encoding IL-17 and IL-17F are localized in the same chromosomal region and are co-expressed by CD4+ and gammadelta T cells. IL-17F can be secreted as homodimers or heterodimers with IL-17. Similar to IL-17, IL-17F utilizes IL-17RA and IL-17RC as its receptor and employs Act1 and TRAF6 as its signal transducers to induce the expression of pro-inflammatory cytokines and chemokines in many different cell types. However, mice lacking either IL-17 or IL-17F exhibit distinct defects in experimental models of asthma and colitis. These results have laid the basis to understand the role of IL-17F in the pathogenesis of human diseases.

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Figures

Figure 1
Figure 1
Overview of IL-17F signaling. Once IL-17F is secreted from CD4 and γδT cells, it is recognized by IL-17RA/RC heteromeric complex. IL-17RA, then, recruits the adaptor molecule, Act1. Act1 activates TRAF6 as well as other transcription factors, leading to induction of cytokines, chemokines and MMPs (matrix metalloproteinase) genes (solid arrow indicates direct influence and dashed arrow indicates possible pathways).
See this image and copyright information in PMC

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