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. 2009 May;61(5):1232-7.
doi: 10.1002/mrm.21932.

Feasibility of single-voxel MRS measurement of apparent diffusion coefficient of water in breast tumors

C A Corum  1 , A D McIntosh, P J Bolan, M Nelson, A L Snyder, N J Powell, J Boyum, T H Emory, D Yee, T M Tuttle, L I Everson, M Garwood
Affiliations

Feasibility of single-voxel MRS measurement of apparent diffusion coefficient of water in breast tumors

C A Corum et al. Magn Reson Med. 2009 May.

Abstract

We report initial results with single voxel spectroscopy (SVS) using diffusion weighting and localization by adiabatic selective refocusing (LASER) in breast tumors to measure the apparent diffusion coefficient of water (ADCw). This is a quick (30 s) and relatively easy method to implement compared with image-based diffusion measurements, and is insensitive to lipid signal contamination. The ADCw and concentration of total choline containing compounds [tCho] were evaluated for associations with each other and final pathologic diagnosis in 25 subjects. The average (+/- SD) ADCw in benign and malignant lesions was 1.96 +/- 0.47 mm(2)/s and 1.26 +/- 0.29 x 10(-3) mm(2)/s, respectively, P< 0.001. Receiver operating characteristic curve analysis showed an area under the curve of 0.92. Analysis of the single voxel (SV) ADCw and [tCho] showed significant correlation with a R(2) of 0.56, P< 0.001. Compared with more commonly used image-based methods of measuring water ADC, SV-ADCw is faster, more robust, insensitive to fat, and potentially easier to implement on standard clinical systems.

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Figures

Fig. 1
Fig. 1
SV-ADC-LASER Sequence.
Fig. 2
Fig. 2
ADC (SV-ADCw) in benign and malignant lesions. The mean (± S.D) ADC in benign lesions was 1.96 ± 0.47 versus 1.26 ± 0.29 × 10-3 mm2/s in malignant masses, p=<0.001.
Fig. 3
Fig. 3
[tCho] in benign and malignant lesions. The average (± S.D.) [tCho] in benign and malignant lesions was 0.95 ± 0.3 and 2.81 ± 1.5 mmol/kg, respectively, p < 0.001.
Fig. 4
Fig. 4
ROC curves for ADC (SV-ADCw) data in Table 1. Biopsy results are the Gold Standard.
Fig. 5
Fig. 5
Performance of the SV-ADCw test at various ADC thresholds.
Fig. 6
Fig. 6
[tCho] versus ADC in benign (blue circles) and malignant (red diamonds) lesions. Inverse regression analysis shows there is a significant inverse correlation between [tCho] and ADC, R2 = 0.56, p < 0.001.
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References

    1. Cecil KM, Schnall MD, Siegelman ES, Lenkinski RE. The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy. Breast Cancer Res Treat. 2001;68(1):45–54. - PubMed
    1. Meisamy S, Bolan PJ, Baker EH, Pollema MG, Le CT, Kelcz F, Lechner MC, Luikens BA, Carlson RA, Brandt KR, Amrami KK, Nelson MT, Everson LI, Emory TH, Tuttle TM, Yee D, Garwood M. Adding in Vivo Quantitative 1H MR Spectroscopy to Improve Diagnostic Accuracy of Breast MR Imaging: Preliminary Results of Observer Performance Study at 4.0 T. Radiology. 2005;236:465–475. - PubMed
    1. Meisamy S, Bolan PJ, Baker EH, Bliss RL, Gulbahce E, Everson LI, Nelson MT, Emory TH, Tuttle TM, Yee D, Garwood M. Neoadjuvant Chemotherapy of Locally Advanced Breast Cancer: Predicting Response with in Vivo 1H MR Spectroscopy-A Pilot Study at 4 T. Radiology. 2004;233:424–431. - PubMed
    1. Bolan PJ, DelaBarre L, Baker EH, Merkle H, Everson LI, Yee D, Garwood M. Eliminating spurious lipid sidebands in 1H MRS of breast lesions. Magnetic Resonance in Medicine. 2002;48(2):215–222. - PubMed
    1. Bolan PJ, Meisamy S, Baker EH, Lin J, Emory T, Nelson M, Everson LI, Yee D, Garwood M. In vivo quantification of choline compounds in the breast with 1H MR spectroscopy. Magn Reson Med. 2003;50(6):1134–1143. - PubMed

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