Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Mar 15;19(6):1600-3.
doi: 10.1016/j.bmcl.2009.02.008. Epub 2009 Feb 8.

Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation

Eduard Badarau  1 , Franck Suzenet, Andrzej J Bojarski, Adriana-Luminiţa Fînaru, Gérald Guillaumet
Affiliations

Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation

Eduard Badarau et al. Bioorg Med Chem Lett. .

Abstract

A new group of serotoninergic 5-HT(1A) or 5-HT(7) receptor ligands was identified. These compounds were designed and synthesized on a benzimidazolone scaffold and they enrich the well-known arylpiperazine class of 5-HT ligands. Diverse pharmacomodulations induced a shift in the affinity and selectivity profile with final identification of new potent hits.

PubMed Disclaimer

LinkOut - more resources