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Comment
. 2009 Mar 3;106(9):E24; author reply E25.
doi: 10.1073/pnas.0900016106. Epub 2009 Feb 23.

DC-SIGN and alpha2,6-sialylated IgG Fc interaction is dispensable for the anti-inflammatory activity of IVIg on human dendritic cells

Jagadeesh Bayry, Kushagra Bansal, Michel D Kazatchkine, Srini V Kaveri
Comment

DC-SIGN and alpha2,6-sialylated IgG Fc interaction is dispensable for the anti-inflammatory activity of IVIg on human dendritic cells

Jagadeesh Bayry et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
IVIg and F(ab′)2 fragments of IVIg mediate anti-inflammatory effect on human dendritic cells. Six-day-old monocyte-derived DC were cultured in the presence of 0.15 mM IVIg or F(ab′)2 fragments of IVIg for 12 h. The cells were then exposed to TLR-4 agonist lipopolysaccharide (1 μg) for 15 and 30 min. The activation of ERK1/2 was monitored by immunoblotting with antibody to phospho-ERK1/2 (Right). An equal amount of protein loaded in each lane was confirmed with immunoblotting by using antibody to the nonphosphorylated form of ERK1/2 (Left).
See this image and copyright information in PMC

Comment on

References

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    1. Bayry J, et al. Natural antibodies sustain differentiation and maturation of human dendritic cells. Proc Natl Acad Sci USA. 2004;101:14210–14215. - PMC - PubMed

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