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. 2009 May;53(5):2215-7.
doi: 10.1128/AAC.01100-08. Epub 2009 Feb 23.

Antibacterial activity of ultrashort cationic lipo-beta-peptides

Griselda N Serrano  1 , George G Zhanel, Frank Schweizer
Affiliations

Antibacterial activity of ultrashort cationic lipo-beta-peptides

Griselda N Serrano et al. Antimicrob Agents Chemother. 2009 May.

Abstract

Previously reported D,L-lipo-alpha-peptides and their lipo-beta-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-beta-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with D,L-amino acid-based lipopeptides or any L-amino acid lipopeptides. As a defined amphipathic structure is unlikely to form with such short molecules and as similar activities were obtained from all lipopeptides, we suspect that the action of membrane permeation is retained.

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