[Binding of 2-acetylaminofluorene-9-14C with rat liver nucleic acids during malignization and in primary hepatomas]
[Article in
Russian]
- PMID: 192387
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[Binding of 2-acetylaminofluorene-9-14C with rat liver nucleic acids during malignization and in primary hepatomas]
[Article in
Russian]
Biull Eksp Biol Med.
1977 Mar.
Abstract
The residual binding of 9-14C-2-Acetylaminofluorene (9-14C-2-AAF) with rat liver nuclei acids was investigated during hepatocarcinogenesis two weeks after a single injection of 9-14C-2-AAF. Up to 6 months feeding of the animals with unlabeled 2-AAF, the RNA of their liver proved to bind increased amounts of 9-14C-2-AAF in comparison with normal liver. The binding of 9-14C-2-AAF with DNA in primary hepatomas was mainly due to the RNA heterodispersed components with the maximum level in the 18S-fraction, as well as with the biopolymere fractions with the sedimentation constant of 10 and 5S enriched with polyadenylate fragments.
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