Case Reports
Interaction of dexamethasone with phenytoin
Affiliations
- PMID: 1923918
Item in Clipboard
Case Reports
Interaction of dexamethasone with phenytoin
Pharmacotherapy.
1991.
Abstract
Phenytoin and dexamethasone are frequently administered concurrently to prevent consequences of central nervous system pathology. Limited and conflicting data are available regarding an interaction between the agents. A patient receiving dexamethasone required a daily phenytoin dose of greater than 10 mg/kg to maintain the phenytoin serum concentration within the usual therapeutic range. The concentration increased by nearly 300% after dexamethasone was discontinued.
Similar articles
-
Possible interaction involving phenytoin, dexamethasone, and antineoplastic agents: a case report and review.Ann Pharmacother. 1996 May;30(5):520-6. doi: 10.1177/106002809603000516. Ann Pharmacother. 1996. PMID: 8740335 Review.
-
Phenytoin/dexamethasone interaction.Lancet. 1978 Jun 24;1(8078):1360. doi: 10.1016/s0140-6736(78)92432-7. Lancet. 1978. PMID: 78122 No abstract available.
-
Dexamethasone/phenytoin interactions: neurooncological concerns.Swiss Med Wkly. 2002 Jul 27;132(29-30):425-6. doi: 10.4414/smw.2002.10085. Swiss Med Wkly. 2002. PMID: 12428189 No abstract available.
-
Phenytoin-dexamethasone interaction: a previously unreported observation.Surg Neurol. 1981 Jul;16(1):23-4. doi: 10.1016/s0090-3019(81)80054-7. Surg Neurol. 1981. PMID: 7280966
-
Decreased phenytoin levels in patients receiving chemotherapy.Am J Med. 1989 Nov;87(5):505-10. doi: 10.1016/s0002-9343(89)80605-9. Am J Med. 1989. PMID: 2683764 Review.
Cited by
-
P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy.J Neurooncol. 2005 May;72(3):255-60. doi: 10.1007/s11060-004-2338-2. J Neurooncol. 2005. PMID: 15937649
-
Corticosteroids for multiple sclerosis: I. Application for treating exacerbations.Neurotherapeutics. 2007 Oct;4(4):618-26. doi: 10.1016/j.nurt.2007.07.008. Neurotherapeutics. 2007. PMID: 17920542 Free PMC article. Review.
-
Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. Clin Pharmacokinet. 2005. PMID: 15634032 Review.
-
Antiepileptic drugs for preventing seizures in people with brain tumors.Cochrane Database Syst Rev. 2008 Apr 16;2008(2):CD004424. doi: 10.1002/14651858.CD004424.pub2. Cochrane Database Syst Rev. 2008. PMID: 18425902 Free PMC article.
-
Brain metastases: treatment options to improve outcomes.CNS Drugs. 2002;16(5):325-38. doi: 10.2165/00023210-200216050-00005. CNS Drugs. 2002. PMID: 11994022 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources