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Case Reports
. 1991;11(4):344-7.

Interaction of dexamethasone with phenytoin

T E Lackner  1
Affiliations
  • PMID: 1923918
Case Reports

Interaction of dexamethasone with phenytoin

T E Lackner. Pharmacotherapy. 1991.

Abstract

Phenytoin and dexamethasone are frequently administered concurrently to prevent consequences of central nervous system pathology. Limited and conflicting data are available regarding an interaction between the agents. A patient receiving dexamethasone required a daily phenytoin dose of greater than 10 mg/kg to maintain the phenytoin serum concentration within the usual therapeutic range. The concentration increased by nearly 300% after dexamethasone was discontinued.

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