Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Mar;7(1):23-6.
doi: 10.1007/s11914-009-0005-4.

Glucocorticoid-induced osteoporosis

Stuart L Silverman  1 , Nancy E Lane
Affiliations
Review

Glucocorticoid-induced osteoporosis

Stuart L Silverman et al. Curr Osteoporos Rep. 2009 Mar.

Abstract

Glucocorticoid treatment can alter bone metabolism, reduce bone strength, and increase the risk for osteoporotic fractures. Risk factors for glucocorticoid-induced osteoporosis (GIO) include older age, high doses, and longer duration of glucocorticoid use. The bone loss that accompanies glucocorticoid use is rapid, and early treatment with bone-sparing agents can prevent bone loss and reduce fracture risk. Several randomized controlled clinical trials have found prevention and treatment of GIO with bisphosphonates, and recently the treatment of GIO with teriparatide, to be effective. This article reviews current information on the epidemiology, pathophysiology, and clinical studies that support using bone-active agents to prevent and treat GIO.

PubMed Disclaimer

References

    1. Rheumatology (Oxford). 2000 Dec;39(12):1383-9 - PubMed
    1. Thorax. 1994 Nov;49(11):1099-102 - PubMed
    1. N Engl J Med. 2007 Nov 15;357(20):2028-39 - PubMed
    1. Arthritis Rheum. 2003 Nov;48(11):3224-9 - PubMed
    1. Ann Intern Med. 1996 Dec 15;125(12):961-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources