Instructing B cell fates on the fringe
- PMID: 19239900
- DOI: 10.1016/j.immuni.2009.01.003
Instructing B cell fates on the fringe
Abstract
The Notch2 ligand DL1 is required for marginal zone B cell development. In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells.
Comment on
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Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches.Immunity. 2009 Feb 20;30(2):254-63. doi: 10.1016/j.immuni.2008.12.016. Epub 2009 Feb 12. Immunity. 2009. PMID: 19217325
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