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Comment
. 2009 Feb 15;23(4):385-90.
doi: 10.1101/gad.1780509.

Maintaining a stochastic neuronal cell fate decision

Daniel Vasiliauskas  1 , Robert Johnston, Claude Desplan
Affiliations
Comment

Maintaining a stochastic neuronal cell fate decision

Daniel Vasiliauskas et al. Genes Dev. .

Abstract

Sensory systems generally contain a number of neuronal subtypes that express distinct sensory receptor proteins. This diversity is generated through deterministic and stochastic cell fate choices, while maintaining the subtype often requires a distinct mechanism. In a study published in the February 1, 2009, issue of Genes & Development, Lesch and colleagues (pp. 345-358) describe a new transcription factor, NSY-7, that acts to stabilize a stochastic subtype choice in AWC chemosensory neurons in Caenorhabditis elegans.

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Figures

Figure 1.
Figure 1.
A model for the role of NSY-7 in establishment and maintenance of stable AWC chemosensory neuron subtypes. See the text for details.
See this image and copyright information in PMC

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