Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Feb 24;106(8):2481-2.
doi: 10.1073/pnas.0813323106.

It's all in a day's work: Regulation of DNA excision repair by the circadian clock

John B Hogenesch  1
Affiliations
Comment

It's all in a day's work: Regulation of DNA excision repair by the circadian clock

John B Hogenesch. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Circadian regulation of XPA and DNA repair activity in the brain. Depicted are the circadian clock (Top Left) regulating XPA mRNA expression. This regulation is accompanied by rhythms in DNA repair activity (Center) in the brain. This repair activity may also be rhythmic in other tissue such as liver and skin.
See this image and copyright information in PMC

Comment on

References

    1. Takahashi JS, Hong HK, Ko CH, McDearmon EL. The genetics of mammalian circadian order and disorder: Implications for physiology and disease. Nat Rev Genet. 2008;9:764–775. - PMC - PubMed
    1. Kang T-K, Reardon JT, Kemp M, Sancar A. Circadian oscillation in nucleotide excision repair in mammalian brain. Proc Natl Acad Sci USA. 2009;106:2864–2867. - PMC - PubMed
    1. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem. 2004;73:39–85. - PubMed
    1. Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006;15:R271–R277. - PubMed
    1. Essen LO, Klar T. Light-driven DNA repair by photolyases. Cell Mol Life Sci. 2006;63:1266–1277. - PMC - PubMed

Substances

LinkOut - more resources