Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jun;118(3):279-90.
doi: 10.1007/s00412-009-0206-8. Epub 2009 Feb 26.

Monoallelic gene expression in mammals

Irina S Zakharova  1 , Alexander I Shevchenko, Suren M Zakian
Affiliations
Review

Monoallelic gene expression in mammals

Irina S Zakharova et al. Chromosoma. 2009 Jun.

Abstract

Three systems of monoallelic gene expression in mammals are known, namely, X-chromosome inactivation, imprinting, and allelic exclusion. In all three systems, monoallelic expression is regulated epigenetically and is frequently directed by long non-coding RNAs (ncRNAs). This review briefs all three systems of monoallelic gene expression in mammals focusing on chromatin modifications, spatial chromosome organization in the nucleus, and the functioning of ncRNAs.

PubMed Disclaimer

References

    1. Genomics. 2001 May 1;73(3):331-7 - PubMed
    1. Dev Cell. 2005 Jul;9(1):159-65 - PubMed
    1. Science. 2007 Dec 7;318(5856):1632-6 - PubMed
    1. Am J Hum Genet. 2002 Aug;71(2):286-93 - PubMed
    1. Development. 2001 Apr;128(8):1275-86 - PubMed

Publication types

Substances

LinkOut - more resources