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. 2009 Feb;24(1):145-54.
doi: 10.1089/cbr.2008.0543.

Quantitative analysis of 90Y Bremsstrahlung SPECT-CT images for application to 3D patient-specific dosimetry

Cinzia Fabbri  1 , Graziella Sarti, Marta Cremonesi, Mahila Ferrari, Amalia Di Dia, Monica Agostini, Francesca Botta, Giovanni Paganelli
Affiliations

Quantitative analysis of 90Y Bremsstrahlung SPECT-CT images for application to 3D patient-specific dosimetry

Cinzia Fabbri et al. Cancer Biother Radiopharm. 2009 Feb.

Abstract

Aim: The aim of this study was to evaluate the accuracy of the activity quantification of single-photon emission computed tomography/computed tomography (SPECT-CT) (90)Y-Bremsstrahlung images and to validate the S-voxel method.

Methods: An anthropomorphic torso phantom with radioactive inserts ((90)Y) was acquired by SPECT-CT. Constant calibration factors (cps/MBq) for the quantification were evaluated, considering different volume, shape, position inside the phantom, activity concentration and background, and distance from detectors. S-voxel values (EGSnrc) were implemented in MATLAB R0086 USA software. Dose comparisons between S-voxel and the conventional Medical Internal Radiation Dose method were repeated in a group of 11 patients administered with (90)Y-DOTATATE.

Results: Using the appropriate calibration factors to recover the volume variability, the error about the measurement repeatability and the activity variation was within 4%. The variability of activity quantification, depending on the position in the phantom, detector distance, and background, was <10%, <5%, and <10%, respectively. The absorbed-dose values calculated by OLINDA were in agreement with the mean dose values obtained by the S-voxel method (difference, <10%).

Conclusions: The results confirm that, with the hybrid SPECT-CT system, quantitative analysis of SPECT (90)Y-Bremsstrahlung images and the generation of three-dimensional dose distributions are feasible. The improved analysis of Bremsstrahlung images could have a notable clinical impact, allowing to address the dosimetric verification to patients during the course of therapy.

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