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Randomized Controlled Trial
. 2009 Feb 25:7:17.
doi: 10.1186/1477-7525-7-17.

A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change

Vivian E von Gruenigen  1 , Heidi E Gibbons, Mary Beth Kavanagh, Jeffrey W Janata, Edith Lerner, Kerry S Courneya
Affiliations
Randomized Controlled Trial

A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change

Vivian E von Gruenigen et al. Health Qual Life Outcomes. .

Abstract

Background: To examine the effects of a 6 month lifestyle intervention on quality of life, depression, self-efficacy and eating behavior changes in overweight and obese endometrial cancer survivors.

Methods: Early stage endometrial cancer survivors were randomized to intervention (n = 23) or usual care (n = 22) groups. Chi-square, Student's t-test and repeated measures analysis of variance were used in intent-to-treat analyses. Outcomes were also examined according to weight loss.

Results: Morbidly obese patients had significantly lower self-efficacy, specifically when feeling physical discomfort. There was a significant improvement for self-efficacy related to social pressure (p = .03) and restraint (p = .02) in the LI group. There was a significant difference for emotional well-being quality of life (p = .02), self-efficacy related to negative emotions (p < .01), food availability (p = .03), and physical discomfort (p = .01) in women who lost weight as compared to women who gained weight. Improvement in restraint was also reported in women who lost weight (p < .01).

Conclusion: This pilot lifestyle intervention had no effect on quality of life or depression but did improve self-efficacy and some eating behaviors.

Trial registration: http://www.clinicaltrials.gov; NCT00420979.

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