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. 1991 Oct 15;88(20):9051-5.
doi: 10.1073/pnas.88.20.9051.

Origin of human chromosome 2: an ancestral telomere-telomere fusion

J W IJdo  1 , A Baldini, D C Ward, S T Reeders, R A Wells
Affiliations

Origin of human chromosome 2: an ancestral telomere-telomere fusion

J W IJdo et al. Proc Natl Acad Sci U S A. .

Abstract

We have identified two allelic genomic cosmids from human chromosome 2, c8.1 and c29B, each containing two inverted arrays of the vertebrate telomeric repeat in a head-to-head arrangement, 5'(TTAGGG)n-(CCCTAA)m3'. Sequences flanking this telomeric repeat are characteristic of present-day human pretelomeres. BAL-31 nuclease experiments with yeast artificial chromosome clones of human telomeres and fluorescence in situ hybridization reveal that sequences flanking these inverted repeats hybridize both to band 2q13 and to different, but overlapping, subsets of human chromosome ends. We conclude that the locus cloned in cosmids c8.1 and c29B is the relic of an ancient telomere-telomere fusion and marks the point at which two ancestral ape chromosomes fused to give rise to human chromosome 2.

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References

    1. J Mol Biol. 1982 Apr 5;156(2):229-43 - PubMed
    1. Cytogenet Cell Genet. 1987;46(1-4):316-24 - PubMed
    1. Hum Genet. 1984;67(4):385-90 - PubMed
    1. Genetics. 1941 Mar;26(2):234-82 - PubMed
    1. Science. 1990 Jan 5;247(4938):64-9 - PubMed