Heparin-induced thrombocytopenia

Abstract

Heparin-Induced Thrombocytopenia (HIT) is a well recognized, potentially life-threatening, complication of heparin therapy. It is associated with an increased risk of thrombosis which can be sometimes fatal. Making the diagnosis of HIT can be quite challenging for the clinician as it requires recognition of the tell-tale clinical presentation as well as positive confirmation with appropriate laboratory diagnostic tests. This paper reviews the pathophysiology, recognition, treatment and prevention of HIT for the clinical physician.