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. 2009 Jun;24(6):1346-9.
doi: 10.1093/humrep/dep044. Epub 2009 Feb 26.

MDM2 309 polymorphism is associated with missed abortion

Yan Fang  1 , Beihua Kong, Qifeng Yang, Daoxin Ma, Xun Qu
Affiliations

MDM2 309 polymorphism is associated with missed abortion

Yan Fang et al. Hum Reprod. 2009 Jun.

Abstract

Background: In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion.

Methods: Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion.

Results: The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T+ T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207-3.878) and villous samples (P = 0.043; OR: 2.767; 95% CI: 1.092-7.011).

Conclusions: The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.

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