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. 2009 Jun 1;179(11):999-1003.
doi: 10.1164/rccm.200812-1929OC. Epub 2009 Feb 26.

Prospective study of physical activity and risk of asthma exacerbations in older women

Judith Garcia-Aymerich  1 , Raphaëlle Varraso, Josep M Antó, Carlos A Camargo Jr
Affiliations

Prospective study of physical activity and risk of asthma exacerbations in older women

Judith Garcia-Aymerich et al. Am J Respir Crit Care Med. .

Abstract

Rationale: The potential role of physical activity in preventing asthma exacerbations is unknown.

Objectives: To investigate the longitudinal association between regular physical activity and asthma exacerbations.

Methods: A total of 2,818 women with asthma from a large U.S. cohort (the Nurses' Health Study) were monitored from 1998 to 2000. Physical activity was self-reported at baseline, using a validated questionnaire, and categorized in quintiles. Exacerbations during follow-up were defined as a self-report of asthma-related hospitalization, emergency department visit, or urgent office visit. Baseline information about severity of asthma, treatment, previous exacerbations, sociodemographic factors, smoking, and other potential confounders was obtained.

Measurements and main results: Participants had a mean age of 63 years, and 71% had mild-to-moderate persistent asthma. About half of the women were ever-smokers (48% former, 6% current), and median physical activity was 10 MET x hours/week (equivalent to walking at a brisk pace for 20 minutes three times per week). Risk of exacerbations during follow-up decreased with increasing level of physical activity. In a multivariate logistic regression model, the higher level of physical activity, the lower risk of admission (odds ratio 0.85, 0.81, 0.78, and 0.76, for the 2nd, 3rd, 4th, and 5th quintiles compared with the 1st quintile, P for trend = 0.05). There were no relevant differences on stratifying by age group, smoking status, body mass index, baseline use of inhaled corticosteroids, or previous exacerbations.

Conclusions: Regular physical activity was associated with reduced risk of exacerbations in women with asthma in this longitudinal study.

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Figures

<b>Figure 1.</b>
Figure 1.
Adjusted probability (and 95% confidence intervals) of asthma exacerbation according to physical activity. From a logistic regression model with physical activity as a continuous variable, and adjusted for age, previous asthma exacerbations, and asthma severity. Outliers (women with physical activity >95th percentile) were excluded.
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References

    1. U.S. Department of Health and Human Services. Physical Activity and Health: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, 1996.
    1. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469–478. - PubMed
    1. Ford ES, Heath GW, Mannino DM, Redd SC. Leisure-time physical activity patterns among US adults with asthma. Chest 2003;124:432–437. - PubMed
    1. Kilpeläinen M, Terho EO, Helenius H, Koskenvuo M. Body mass index and physical activity in relation to asthma and atopic diseases in young adults. Respir Med 2006;100:1518–1525. - PubMed
    1. Chen Y, Dales R, Krewski D. Leisure-time energy expenditure in asthmatics and non-asthmatics. Respir Med 2001;95:13–18. - PubMed

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