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. 2009 Feb;63(1):65-9.
doi: 10.18926/AMO/31855.

Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column

Masahiro Nishibori  1 , Hideo K Takahashi, Hiroshi Katayama, Shuji Mori, Shinya Saito, Hiromi Iwagaki, Noriaki Tanaka, Kiyoshi Morita, Aiji Ohtsuka
Affiliations
Free article

Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column

Masahiro Nishibori et al. Acta Med Okayama. 2009 Feb.
Free article

Abstract

Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been used for the treatment of LPS-induced septic shock. In this study, we demonstrated that PMX also specifically bound monocytes from the peripheral blood leukocytes of septic patients by mean of an analysis of bound cells using immunocytochemical and electron microscopic techniques. The specific removal of monocytes from septic patients may produce beneficial effects by reducing the interaction between monocytes and functionally associated cells including vascular endothelial cells.

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