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Case Reports
. 2009 Feb 28;15(8):1014-7.
doi: 10.3748/wjg.15.1014.

Nodular liver lesions involving multiple myeloma: a case report and literature review

Xiao-Ning Wu  1 , Xin-Yan Zhao, Ji-Dong Jia
Affiliations
Case Reports

Nodular liver lesions involving multiple myeloma: a case report and literature review

Xiao-Ning Wu et al. World J Gastroenterol. .

Abstract

We report a case of a 62-year old woman admitted to our hospital for multiple nodular metastatic liver lesions found by ultrasonography in a regular medical examination. Routine laboratory tests were normal. PET-CT showed multiple bone lesions and nodular liver lesions. Liver biopsy revealed nodular infiltration of multiple myeloma with positive staining of kappa light chain. Further investigation of bone marrow aspiration, immunofixation and immunoelectrophoresis of serum protein, urine test for Bence-Jones protein, beta(2)-microglobulin in serum and urine confirmed the diagnosis. The patient also coinfected with hepatitis C virus (HCV). With six cycles of chemotherapy with VAD schedule, she achieved complete remission. In this report, a literature review of liver lesions involving multiple myeloma is also provided.

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Figures

Figure 1
Figure 1
Multiple osteolytic bone lesions and nodular liver lesions (PET-CT).
Figure 2
Figure 2
Nodular plasma cell infiltration in liver: myeloma on the right, liver tissue on the left and steatosis in the middle (HE-20 ×).
Figure 3
Figure 3
Plasma cell infiltration in liver (HE-60 ×).
Figure 4
Figure 4
Positive staining of kappa light chain by immunohistochemistry in liver (60 ×).
Figure 5
Figure 5
Plasmacytosis in bone marrow (HE-60 ×).
See this image and copyright information in PMC

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