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Review
. 1991 Aug;21(4):277-81.
doi: 10.1016/0167-8140(91)90054-k.

Renal damage in mice after sequential cisplatin and irradiation: the influence of prior irradiation on platinum elimination

F A Stewart  1 , H Bartelink, G B van der Voet, F A de Wolff
Affiliations
Review

Renal damage in mice after sequential cisplatin and irradiation: the influence of prior irradiation on platinum elimination

F A Stewart et al. Radiother Oncol. 1991 Aug.

Abstract

Doses of 4-6 mg kg-1 c-DDP given 6 months before renal irradiation caused only a modest increase in functional radiation damage (DEF 1.1). These effects could be explained by additive toxicities and the damage was much less than when c-DDP was given 3-6 months after irradiation. Pharmacokinetic studies did not demonstrate any decrease in the rate of platinum elimination after previous low-dose renal irradiation.

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