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Randomized Controlled Trial
. 2009 Mar:32 Suppl 1:S231-5.
doi: 10.1111/j.1540-8159.2008.02293.x.

Impact of AV conduction disorders on SafeR mode performance

Bernard Thibault  1 , Christopher Simpson, Carl-Eric Gagné, Louis Blier, Manohara Senaratne, Serge McNicoll, Carlo Stuglin, Randy Williams, Arnold Pinter, Yaariv Khaykin, Remi Nitzsche
Affiliations
Randomized Controlled Trial

Impact of AV conduction disorders on SafeR mode performance

Bernard Thibault et al. Pacing Clin Electrophysiol. 2009 Mar.

Abstract

Purpose: CAN-SAVE R is a Canadian multicenter study that compares the effects of a new pacing mode algorithm designed to minimize right ventricular (V) pacing versus DDD mode with a long atrioventricular (AV) delay in a general population of pacemaker (PM) recipients.

Study participants: Patients with permanent atrial fibrillation (AF) or high-degree AV block (AVB) were excluded. We present preliminary data collected in 208 patients (mean age=71 +/- 11 years, 68% men), for the 2-month baseline period during which all PM were programmed in the new pacing mode. The pacing indications were sinus node disease (SND) without AVB in 39%, AVB without SND in 30%, SND and AVB in 16%, and miscellaneous in 15% of patients.

Results: The mean percent V pacing in the overall population was 9.5 +/- 23.8% (range=0-100%, median <1%), ranging between 0.5 +/- 1.5% (median=0) in patients without AVB and 18.7 +/- 31.2% in patients (median = 1) with AVB. Adverse events potentially related to the new pacing mode were observed in two patients with AVB.

Conclusions: A new pacing mode was effective and safe in a general population of PM recipients without permanent AVB and was associated with an overall <1% median V pacing. CAN-SAVE R will compare the long-term effects of the new pacing mode with DDD with a long AV delay on clinical outcomes and cardiac function.

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