Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 May;156(2):185-8.
doi: 10.1111/j.1365-2249.2009.03887.x. Epub 2009 Jan 22.

Translating transplantation tolerance in the clinic: where are we, where do we go?

M Goldman  1 , K Wood
Affiliations
Review

Translating transplantation tolerance in the clinic: where are we, where do we go?

M Goldman et al. Clin Exp Immunol. 2009 May.

Abstract

Research networks dedicated to translation of immune tolerance in the clinic currently support pilot trials aiming at immunosuppression withdrawal in kidney or liver allograft recipients. Although results obtained so far indicate that significant hurdles still need to be overcome before organ transplant recipients can be weaned off drugs safely and routinely, recent advances suggest that immunosuppression minimization on the basis of validated biomarkers might become standard practice in a near future.

PubMed Disclaimer

References

    1. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance’ of foreign cells. Nature. 1953;172:603–6. - PubMed
    1. Sykes M. Mixed chimerism and transplant tolerance. Immunity. 2001;14:417–24. - PubMed
    1. Dey B, Sykes M, Spitzer TR. Outcomes of recipients of both bone marrow and solid organ transplants. A review. Medicine (Baltimore) 1998;77:355–69. - PubMed
    1. Hamawi K, De Magalhaes-Silverman M, Bertolatus JA. Outcomes of renal transplantation following bone marrow transplantation. Am J Transplant. 2003;3:301–5. - PubMed
    1. Monaco AP, Clark AW, Wood ML, Sahyoun AI, Codish SD, Brown RW. Possible active enhancement of a human cadaver renal allograft with antilymphocyte serum (ALS) and donor bone marrow: case report of an initial attempt. Surgery. 1976;79:384–92. - PubMed

Publication types

MeSH terms