Effect of thyroxine and of thyrotropin releasing hormone on cyclic AMP concentration in the anterior pituitary gland in vitro
- PMID: 192536
Item in Clipboard
Effect of thyroxine and of thyrotropin releasing hormone on cyclic AMP concentration in the anterior pituitary gland in vitro
Endocrinol Exp.
1977 Mar.
Abstract
The effect TRH and thyroxine (T4) in vitro on the content of cAMP in the anterior pituitary gland in rat have been investigated. Thyroxine did not significantly affect this concentration, but TRH produced approximately a two-fold increase in the pituitary cAMP content. Preincubation of the anterior pituitary together with T4--under the conditions when the latter inhibited both proliferative and secretory response of the gland to TRH--did not prevent the elevation of cAMP due to TRH. It is assumed that T4 must have exerted its inhibitory effect outside of the cyclic AMP system.
Similar articles
-
Effect of thyroid hormone, actinomycin D, cycloheximide and puromycin on TRH-induced secretion of TSH, as studied by pituitary concentration of cyclic AMP and intrathyroidal colloid droplet formation.Arch Int Pharmacodyn Ther. 1978 Jul;234(1):145-55. Arch Int Pharmacodyn Ther. 1978. PMID: 213036
-
In vitro effect of TRH on adenylate cyclase and cAMP in rat anterior pituitary and on TSH and PRL release into incubation medium.Endocrinol Exp. 1980 Dec;14(4):291-6. Endocrinol Exp. 1980. PMID: 6257479
-
Karyometric investigations on the influence of thyroidectomy, thyroxine and TRH upon the rat anterior pituitary.Endocrinol Exp. 1977 Sep;11(3):175-81. Endocrinol Exp. 1977. PMID: 412659 No abstract available.
-
Mechanism of action of luteinizing hormone releasing hormone and thyrotropin releasing hormone in the anterior pituitary gland and modulation of their activity by peripheral hormones.Adv Exp Med Biol. 1977;87:157-79. doi: 10.1007/978-1-4615-8849-8_8. Adv Exp Med Biol. 1977. PMID: 197831 Review. No abstract available.
-
Role of cyclic AMP in the action of hypothalamic regulatory hormones.Adv Cyclic Nucleotide Res. 1975;5:787-801. Adv Cyclic Nucleotide Res. 1975. PMID: 165698 Review. No abstract available.
Cited by
-
Studies of the mechanism by which 3,5,3'- triiodothyronine stimulates 2-deoxyglucose uptake in rat thymocytes in vitro. Role of calcium and adenosine 3':5'-monophosphate.J Clin Invest. 1981 Jul;68(1):103-10. doi: 10.1172/jci110224. J Clin Invest. 1981. PMID: 6265495 Free PMC article.