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Review
. 2009 Jun;119(6):349-55.
doi: 10.1111/j.1600-0404.2008.01137.x. Epub 2009 Feb 26.

Translating pathology in multiple sclerosis: the combination of postmortem imaging, histopathology and clinical findings

A Seewann  1 , E-J Kooi, S D Roosendaal, F Barkhof, P van der Valk, J J G Geurts
Affiliations
Review

Translating pathology in multiple sclerosis: the combination of postmortem imaging, histopathology and clinical findings

A Seewann et al. Acta Neurol Scand. 2009 Jun.

Abstract

Background: Studies combining postmortem magnetic resonance imaging (MRI) and histopathology have provided important insights into the abnormalities reflected by MRI.

Materials and methods: A short overview of these studies applied to multiple sclerosis (MS) is provided in this review, and the Amsterdam postmortem imaging protocol is specifically highlighted.

Conclusion: Postmortem MRI and histopathology correlation studies have enabled a direct translation of basic pathology in MS to the clinical setting, and have simultaneously served as a biological validation of new MRI techniques.

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