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Multicenter Study
. 2009 Mar 17;119(10):1417-23.
doi: 10.1161/CIRCULATIONAHA.108.806307. Epub 2009 Mar 2.

Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study

Catherine Amlie-Lefond  1 , Timothy J Bernard, Guillaume Sébire, Neil R Friedman, Geoffrey L Heyer, Norma B Lerner, Gabrielle DeVeber, Heather J Fullerton; International Pediatric Stroke Study Group
Affiliations
Multicenter Study

Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study

Catherine Amlie-Lefond et al. Circulation. .

Abstract

Background: Cerebral arteriopathies, including an idiopathic focal cerebral arteriopathy of childhood (FCA), are common in children with arterial ischemic stroke and strongly predictive of recurrence. To better understand these lesions, we measured predictors of arteriopathy within a large international series of children with arterial ischemic stroke.

Methods and results: Between January 2003 and July 2007, 30 centers within the International Pediatric Stroke Study enrolled 667 children (age, 29 days to 19 years) with arterial ischemic stroke and abstracted clinical and radiographic data. Cerebral arteriopathy and its subtypes were defined using published definitions; FCA was defined as cerebral arterial stenosis not attributed to specific diagnoses such as moyamoya, arterial dissection, vasculitis, or postvaricella angiopathy. We used multivariate logistic regression techniques to determine predictors of arteriopathy and FCA among those subjects who received vascular imaging. Of 667 subjects, 525 had known vascular imaging results, and 53% of those (n=277) had an arteriopathy. The most common arteriopathies were FCA (n=69, 25%), moyamoya (n=61, 22%), and arterial dissection (n=56, 20%). Predictors of arteriopathy include early school age (5 to 9 years), recent upper respiratory infections, and sickle cell disease, whereas prior cardiac disease and sepsis reduced the risk of arteriopathy. The only predictor of FCA was recent upper respiratory infection.

Conclusions: Arteriopathy is prevalent among children with arterial ischemic stroke, particularly those presenting in early school age, and those with a history of sickle cell disease. Recent upper respiratory infection predicted cerebral arteriopathy and FCA in particular, suggesting a possible role for infection in the pathogenesis of these lesions.

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Conflict of interest statement

Conflicts of Interest Disclosures: None.

Figures

Figure 1
Figure 1
Flow diagram demonstrating exclusion criteria and final study population. IPSS=International Pediatric Stroke Study; CSVT=cerebral sinovenous thrombosis; AIS=arterial ischemic stroke.
See this image and copyright information in PMC

Comment in

References

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