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Comment
. 2009 Mar;11(3):235-6.
doi: 10.1038/ncb0309-235.

Prions tunnel between cells

Hans-Hermann Gerdes  1
Affiliations
Comment

Prions tunnel between cells

Hans-Hermann Gerdes. Nat Cell Biol. 2009 Mar.

Abstract

Prions are abnormal isoforms of host proteins that are the infectious agents in certain mammalian neurodegenerative diseases. How prions travel from their peripheral entry sites to the brain where they cause disease is poorly understood. A new study finds that tunnelling nanotubes are important for the intercellular transfer of prions during neuroinvasion.

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  • Prions hijack tunnelling nanotubes for intercellular spread.
    Gousset K, Schiff E, Langevin C, Marijanovic Z, Caputo A, Browman DT, Chenouard N, de Chaumont F, Martino A, Enninga J, Olivo-Marin JC, Männel D, Zurzolo C. Gousset K, et al. Nat Cell Biol. 2009 Mar;11(3):328-36. doi: 10.1038/ncb1841. Epub 2009 Feb 8. Nat Cell Biol. 2009. PMID: 19198598

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