Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx

Abstract

Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical office-based laryngoscopy examination is presented. An optical-ballast-based 4f optical relay system is proposed to realize variable working distance with a constant optical delay. In-vivo OCT imaging of the human larynx is demonstrated. Office-based OCT is a promising imaging modality for early laryngeal cancer diagnosis.

Fig. 1

(a) Schematic diagram of the long GRIN-lens-based laryngeal SDOCT imaging system. (b) 3-D design of laryngeal OCT probe, and (c) the formation of 4f optical relay system based on optical ballast.

Fig. 2

(a) OCT probe attached to the laryngoscope; (b) defogging before (c) insertion of the probe into pharynx for examination; and (d) dual-channel office-based OCT laryngeal probe in use during laryngeal examination.

Fig. 3

The double-barreled configuration helps physicians to find the working distance. ▼ shows the OCT scanning range at a long working distance, while ● shows the OCT scanning range at a short working distance and its video projection onto the long working distance case.

Video 1

OCT images from the epiglottis under examination of the office-based laryngeal probe. The epithelium, lamina propria and glands are clearly identified. (QuickTime, 9.9 MB). [URL: http://dx.doi.org/10.1117/1.3076198.1]