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Editorial
. 2008 Dec;79(3):165-71.

The dilemma of the nonthyroidal illness syndrome

Ronald M Lechan
Editorial

The dilemma of the nonthyroidal illness syndrome

Ronald M Lechan. Acta Biomed. 2008 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Neuroregulatory control systems involved in the secretion of thyroid hormone. Bold lines denote the negative feedback loop of thyroid hormone on thyrotropin-releasing hormone (TRH) secretion from the hypothalamus and TSH secretion from the anterior pituitary. Both the hypothalamic TRH neurons and anterior pituitary thyrotropes are impinged upon by numerous other potential regulatory influences that are activated under specific physiological or pathological conditions. PVN = paraventricular nucleus; ARC = arcuate nucleus, ME = median eminence; III = third ventricle (Courtesy, Dr. Praful Singru, Tufts Medical Center)
Figure 2
Figure 2
Regulation of hypophysiotropic TRH neurons by leptin-sensitive hypothalamic arcuate nucleus neurons. Two, major sets of neurons are noted including those that produce AGRP/NPY, that inhibit TRH neurons through Y1 and Y5 receptors (Y1/Y5R), and α-MSH, that stimulates TRH neurons through the MC4 receptor (MC4R). CART also activates TRH neurons but by an unknown mechanism(s). Reciprocal, inhibitory interactions between NPY/AGRP and α-MSH neurons also occur. The location of tanycyte cell bodies in the floor and infralateral walls of the third ventricle and their cytoplasmic projections are depicted in the left half of the diagram (Courtesy, Dr. Praful Singru, Tufts Medical Center)
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References

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