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Review
. 2009 Apr;20(2):185-91.
doi: 10.1016/j.cytogfr.2009.02.002. Epub 2009 Mar 3.

Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease

Giovanni Monteleone  1 , Francesco Pallone, Thomas T Macdonald
Affiliations
Review

Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease

Giovanni Monteleone et al. Cytokine Growth Factor Rev. 2009 Apr.

Abstract

Interleukin-21 (IL-21) is produced mostly by activated CD4+ T cells and controls the differentiation and functional activity of effector T helper cells, counteracts the suppressive effects of regulatory T cells, and stimulates non-immune cells to make inflammatory mediators. IL-21-driven tissue damage has been demonstrated in a number of organs, such as the gut, pancreas, and brain. Therefore new treatment modalities to neutralise IL-21 in vivo would be a valuable addition to the therapeutic armamentarium to combat immune-mediated inflammation. Here we describe the emerging role of IL-21 in the initiation and progress of the tissue-damaging inflammatory response in immune-mediated pathologies.

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