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. 1977 Apr;13(2):153-7.
doi: 10.1007/BF00745144.

Effect of experimental diabetes and glucagon on cAMP-dependent protein kinase in rat liver

H E Weber, L A Menahan, S N Chaudhuri, J C Shipp

Effect of experimental diabetes and glucagon on cAMP-dependent protein kinase in rat liver

H E Weber et al. Diabetologia. 1977 Apr.

Abstract

Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+cAMP) and an increase in the activity ratio (-cAMP) divided by (+cAMP) in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in liver. Glucagon administered in vivo to normal rats caused an increase in the activity ratio and a decrease in total protein kinase activity in liver. The changes are similar to those in diabetes. A decrease in the ratio of insulin to glucagon in diabetes may account for the changes in protein kinase observed.

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