Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Mar 4;28(5):455-6.
doi: 10.1038/emboj.2009.18.

RNF11, a new piece in the A20 puzzle

Emilie Jacque  1 , Steven C Ley
Affiliations
Comment

RNF11, a new piece in the A20 puzzle

Emilie Jacque et al. EMBO J. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Regulation of TNFR1 signalling by ubiquitination. (A) TNF stimulation induces binding of a TRADD–RIP1–TRAF2–TRAF5 complex to TNFR1. The TRAF proteins then catalyse the K63-linked polyubiquitination of RIP1, inducing RIP1 association with the IKK complex (IKK1/IKK2/NEMO), which is subsequently activated by a process that involves both its K63-linked ubiquitination and phosphorylation. IKK phosphorylates IκBα, triggering K48-linked polyubiquitination of IκBα, which induces its subsequent degradation by the proteasome. As a result, associated NF-κB dimers are freed to translocate into the nucleus and activate the transcription of NF-κB target genes, including A20. (B) The A20 ubiquitin-editing complex is critical to ensure that NF-κB activation induced by TNF is transient. This complex, comprising A20, TAX1BP1, Itch and RNF11, catalyses the removal of K63-linked ubiquitin chains from RIP1, utilizing the deubiquitinating activity of A20. Subsequently, A20 and Itch catalyse addition of K48-linked ubiquitin chains of RIP1, promoting its degradation by the proteasome and termination of NF-κB activation. K63-linked ubiquitin chains, purple; K48-linked ubiquitin chains, turquoise; P, phosphorylation; Ub, ubiquitin; +Ub, ubiquitination; −Ub, deubiquitination.
See this image and copyright information in PMC

Comment on

References

    1. Azmi P, Seth A (2005) RNF11 is a multifunctional modulator of growth factor receptor signalling and transcription regulation. Eur J Cancer 41: 2549–2560 - PubMed
    1. Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004) Functional proteomics mapping of a human signaling pathway. Genome Res 14: 1324–1332 - PMC - PubMed
    1. Coornaert B, Carpentier I, Beyaert R (2008) A20: central gatekeeper in inflammation and immunity. J Biol Chem (e-pub ahead of print; doi:10.1074/jbc.R800032200) - PMC - PubMed
    1. Heissmeyer V, Rao A (2008) Itching to end NF-κB. Nat Immunol 9: 227–229 - PubMed
    1. Iha H, Peloponese J-M, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang K-T (2008) Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation. EMBO J 27: 629–641 - PMC - PubMed