Fatal Epstein-Barr virus encephalitis in a 12-year-old child: an underappreciated neurological complication?

doi:10.1038/ncpneuro1043

Case Reports

. 2009 Mar;5(3):171-4.

doi: 10.1038/ncpneuro1043.

Fatal Epstein-Barr virus encephalitis in a 12-year-old child: an underappreciated neurological complication?

Ariane Biebl¹, Christine Webersinke, Bernadette Traxler, Brigitte Povysil, Dieter Furthner, Klaus Schmitt, Serge Weis

Affiliations

PMID: 19262593
DOI: 10.1038/ncpneuro1043

Case Reports

Fatal Epstein-Barr virus encephalitis in a 12-year-old child: an underappreciated neurological complication?

Ariane Biebl et al. Nat Clin Pract Neurol. 2009 Mar.

. 2009 Mar;5(3):171-4.

doi: 10.1038/ncpneuro1043.

Authors

Ariane Biebl¹, Christine Webersinke, Bernadette Traxler, Brigitte Povysil, Dieter Furthner, Klaus Schmitt, Serge Weis

Affiliation

¹ Department of Pediatrics, Children's Hospital, Linz, Austria. ariane.biebl@gespag.at

PMID: 19262593
DOI: 10.1038/ncpneuro1043

Abstract

Background: A 12-year-old boy presented to a community hospital with fever, malaise and fatigue. A polymerase chain reaction test of the cerebrospinal fluid was positive for Epstein-Barr virus. Despite intensive care treatment and antiviral drugs, the patient died 1 month after his initial presentation.

Investigations: Physical examination, polymerase chain reaction analysis of the cerebrospinal fluid, brain MRI, immunohistochemistry and molecular biological investigations of postmortem brain samples.

Diagnosis: Epstein-Barr Virus encephalitis.

Management: Aciclovir, intensive care treatment with intubation, sedation, antiepileptic drugs.

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References

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[1] Rinsho Shinkeigaku. 2007 Aug;47(8):497-501 - PubMed

[2] Rinsho Shinkeigaku. 2007 Aug;47(8):497-501 - PubMed

[3] J Child Neurol. 2006 May;21(5):384-91 - PubMed

[4] J Child Neurol. 2006 May;21(5):384-91 - PubMed

[5] Am J Med. 1988 Aug 29;85(2A):107-15 - PubMed

[6] Am J Med. 1988 Aug 29;85(2A):107-15 - PubMed

[7] Pediatr Neurol. 1994 May;10(3):181-4 - PubMed

[8] Pediatr Neurol. 1994 May;10(3):181-4 - PubMed

[9] Arch Neurol. 1972 Apr;26(4):353-8 - PubMed

[10] Arch Neurol. 1972 Apr;26(4):353-8 - PubMed

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Fatal Epstein-Barr virus encephalitis in a 12-year-old child: an underappreciated neurological complication?

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Fatal Epstein-Barr virus encephalitis in a 12-year-old child: an underappreciated neurological complication?

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