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Comparative Study
. 2009 Aug;72(3):595-9.
doi: 10.1016/j.ejpb.2009.02.009. Epub 2009 Mar 3.

Electroosmotic flow as a result of buccal iontophoresis--buccal mucosa properties

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Comparative Study

Electroosmotic flow as a result of buccal iontophoresis--buccal mucosa properties

Aleksandra Moscicka-Studzinska et al. Eur J Pharm Biopharm. 2009 Aug.

Abstract

The objective of this study was to investigate and to better understand the properties of buccal mucosa as a semipermeable membrane and a portal for drug administration by iontophoretic and electroosmotic means. In vitro experiments showed that buccal mucosa at the pH of about 7.4 behaved as a cation-exchange membrane and non-linear resistor. It had lower resistance and was more permeable for water than a skin. The electroosmotic volume flow through mucosa depended on current density, mucosa resistance and electrolyte concentration. Sodium dodecyl sulfate (in concentration range 0.001-0.005 mol L(-1)) and urea (in concentration range 0.42-1.67 mol L(-1)) did not promote a water transfer through buccal mucosa, however, both substances enhanced flow through the skin.

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