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Review
. 2009 Mar 6;323(5919):1304-7.
doi: 10.1126/science.1165706.

The challenge of finding a cure for HIV infection

Douglas D Richman  1 , David M Margolis, Martin Delaney, Warner C Greene, Daria Hazuda, Roger J Pomerantz
Affiliations
Review

The challenge of finding a cure for HIV infection

Douglas D Richman et al. Science. .

Abstract

Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent infection in reservoirs such as latently infected CD4+ lymphocytes and cells of the macrophage-monocyte lineage. Despite its success, chronic suppressive therapy is limited by its cost, the requirement of lifelong adherence, and the unknown effects of long-term treatment. This review discusses our current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure.

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Comment in

  • A step ahead on the HIV collaboratory.
    Murphy RL, Autran B, Katlama C, Brucker G, Debre P, Calvez V, Clotet B, Clumeck N, Costagliola D, Deeks SG, Dorrell L, Gatell J, Haase A, Klein M, Lazzarin A, McMichael AJ, Papagno L, Schacker TW, Wain-Hobson S, Walker BD, Youle M. Murphy RL, et al. Science. 2009 Jun 5;324(5932):1264-5. doi: 10.1126/science.324_1264b. Science. 2009. PMID: 19498149 No abstract available.