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Multicenter Study
. 2009 Jun;32(6):1046-8.
doi: 10.2337/dc08-2061. Epub 2009 Mar 5.

Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes

Dorte M Jensen  1 , Lars Korsholm, Per Ovesen, Henning Beck-Nielsen, Lars Moelsted-Pedersen, Jes G Westergaard, Margrethe Moeller, Peter Damm
Affiliations
Multicenter Study

Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes

Dorte M Jensen et al. Diabetes Care. 2009 Jun.

Abstract

Objective: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality).

Research design and methods: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes.

Results: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%.

Conclusions: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.

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