The side story of stem-like glioma cells
- PMID: 19265652
- DOI: 10.1016/j.stem.2009.02.004
The side story of stem-like glioma cells
Abstract
In this issue of Cell Stem Stell, Bleau et al. report that activity of the drug transporter ABCG2 defines a tumorigenic stem-like side population (SP) isolated from glioma. Surprisingly, temozolomide, the first-line chemotherapeutic used for treatment of glioma, increased this side population, and even more so when PTEN was deleted.
Comment on
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PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.Cell Stem Cell. 2009 Mar 6;4(3):226-35. doi: 10.1016/j.stem.2009.01.007. Cell Stem Cell. 2009. PMID: 19265662 Free PMC article.
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