When integrins fail to integrate
- PMID: 19265824
- PMCID: PMC4112414
- DOI: 10.1038/nm0309-249
When integrins fail to integrate
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Comment on
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A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans.Nat Med. 2009 Mar;15(3):313-8. doi: 10.1038/nm.1917. Epub 2009 Feb 22. Nat Med. 2009. PMID: 19234460 Free PMC article.
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Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.Nat Med. 2009 Mar;15(3):300-5. doi: 10.1038/nm.1921. Epub 2009 Feb 22. Nat Med. 2009. PMID: 19234461
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Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.Nat Med. 2009 Mar;15(3):306-12. doi: 10.1038/nm.1931. Epub 2009 Feb 22. Nat Med. 2009. PMID: 19234463 Free PMC article.
References
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- Anderson DC, Springer TA. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med. 1987;38:175–194. - PubMed
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- Alon R, Etzioni A. LAD-III, a novel group of leukocyte integrin activation deficiencies. Trends Immunol. 2003;24:561–566. - PubMed
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- Kindler T. Congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophy. Br J Dermatol. 1954;66:104–111. - PubMed
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