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. 2008 Feb 24:2008:1-3.
doi: 10.1117/2.1200801.1014.

Harnessing the cell's own ability to repair and prevent neurodegenerative disease

Harry Whelan  1 , Kristina Desmet, Ellen Buchmann, Michele Henry, Margaret Wong-Riley, Janis Eells, James Verhoeve
Affiliations

Harnessing the cell's own ability to repair and prevent neurodegenerative disease

Harry Whelan et al. SPIE Newsroom. .

Abstract

Near-IR light treatment modifies cellular function, promotes cell survival, and improves outcomes in laboratory and mouse models of Parkinson's disease.

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Figures

Figure 1
Figure 1
670nm near-IR light treatment attenuates potassium cyanide (KCN)-induced apoptosis (i.e., programed cell death) in primary cultured neurons. Primary visual cortical neurons subdivided into 3 groups: (A) control, (B) exposed to 300μM KCN for 28 h, and (C) pretreatment with 670nm light for 10 min before exposure to 300μM KCN for 28 h. Cultures were then stained with propidium iodide for neurons undergoing cell death (arrows).
Figure 2
Figure 2
Cytochrome oxidase and the correlation between the near-IR absorption spectrum of cytochrome oxidase, ATP content, and cytochrome oxidase activity in cultured primary neuronal cells subjected to metabolic inhibition and near-IR light treatment.
Figure 3
Figure 3
670nm light treatment attenuates MPP+ cytotoxicity in human dopaminergic cells expressing A30P mutant α-synuclein. Results expressed as mean values ± SE of replicated culture wells within an experiment. Differences between groups determined by one-way ANOVA. ** p< 0.05.
Figure 4
Figure 4
670nm light pretreatment ameliorates the toxicity of the Parkinsonian drug MPTP
See this image and copyright information in PMC

References

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