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. 1977 Mar;15(3):772-5.
doi: 10.1128/iai.15.3.772-775.1977.

Reliable in vivo model for latent herpes simplex virus reactivation with peripheral virus shedding

A B Nesburn, M T Green, M Radnoti, B Walker

Reliable in vivo model for latent herpes simplex virus reactivation with peripheral virus shedding

A B Nesburn et al. Infect Immun. 1977 Mar.

Abstract

A long-sought laboratory model, a reliable system for in vivo reactivization of latent herpes simplex infection with peripheral shedding of active virus, is present. Results demonstrate that surgical stimulation of latently infected rabbit trigeminal ganglia induces peripheral release of infectious herpes simplex virus. Virus could be cultured from the tear film in 83% of the stimulated animals' eyes within 48 h.

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