doi: 10.1016/j.bbrc.2009.02.157.
Epub 2009 Mar 4.
A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi
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- PMID: 19268431
- DOI: 10.1016/j.bbrc.2009.02.157
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A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi
Biochem Biophys Res Commun.
.
Abstract
Quorum sensing has attracted much attention due to its involvement in pathologically relevant events such as biofilm formation, virulence factor production, and sporulation. Inhibitors of quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe a phenothiazine structural scaffold as a new type of quorum sensing inhibitors with IC(50) values in the single digit micro molar range in Vibrio harveyi.
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