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. 2009 Apr;12(4):393-5.
doi: 10.1038/nn.2286. Epub 2009 Mar 8.

D2R striatopallidal neurons inhibit both locomotor and drug reward processes

Pierre F Durieux  1 , Bertrand Bearzatto, Stefania Guiducci, Thorsten Buch, Ari Waisman, Michele Zoli, Serge N Schiffmann, Alban de Kerchove d'Exaerde
Affiliations
Free article

D2R striatopallidal neurons inhibit both locomotor and drug reward processes

Pierre F Durieux et al. Nat Neurosci. 2009 Apr.
Free article

Abstract

The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.

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