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. 2009 May;45(8):1510-7.
doi: 10.1016/j.ejca.2009.01.028. Epub 2009 Mar 9.

The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

Donal J Brennan  1 , Sara Ek, Emma Doyle, Thomas Drew, Michael Foley, Grainne Flannelly, Darran P O'Connor, William M Gallagher, Sami Kilpinen, Olli-Pekka Kallioniemi, Karin Jirstrom, Colm O'Herlihy, Carl A K Borrebaeck
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The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

Donal J Brennan et al. Eur J Cancer. 2009 May.

Abstract

Background: Current prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC.

Methods: Using an in silico transcriptomic screen, Sox11 was identified as a potential EOC biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC) in 76 EOC cases, which were analysed using automated algorithms to develop a quantitative scoring model.

Results: Sox11 mRNA expression was upregulated in EOC compared to normal tissues. Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in 40% of tumours, who had an improved recurrence-free survival (RFS) (p=0.002). Multivariate analysis confirmed that Sox11 was an independent predictor of improved RFS after controlling for stage and grade.

Conclusions: These data suggest that Sox11 is a new prognostic marker in EOC. Loss of Sox11 is associated with a decreased RFS and a more aggressive phenotype.

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