Comment on

• Opportunities for enzyme engineering in natural product biosynthesis.

  Bernhardt P, O'Connor SE. Bernhardt P, et al. Curr Opin Chem Biol. 2009 Feb;13(1):35-42. doi: 10.1016/j.cbpa.2009.01.005. Epub 2009 Feb 5. Curr Opin Chem Biol. 2009. PMID: 19201253 Free PMC article. Review.
• Enzyme (re)design: lessons from natural evolution and computation.

  Gerlt JA, Babbitt PC. Gerlt JA, et al. Curr Opin Chem Biol. 2009 Feb;13(1):10-8. doi: 10.1016/j.cbpa.2009.01.014. Epub 2009 Feb 23. Curr Opin Chem Biol. 2009. PMID: 19237310 Free PMC article. Review.
• Directed enzyme evolution: climbing fitness peaks one amino acid at a time.

  Tracewell CA, Arnold FH. Tracewell CA, et al. Curr Opin Chem Biol. 2009 Feb;13(1):3-9. doi: 10.1016/j.cbpa.2009.01.017. Epub 2009 Feb 25. Curr Opin Chem Biol. 2009. PMID: 19249235 Free PMC article. Review.
• Advances in generating functional diversity for directed protein evolution.

  Shivange AV, Marienhagen J, Mundhada H, Schenk A, Schwaneberg U. Shivange AV, et al. Curr Opin Chem Biol. 2009 Feb;13(1):19-25. doi: 10.1016/j.cbpa.2009.01.019. Epub 2009 Mar 2. Curr Opin Chem Biol. 2009. PMID: 19261539 Review.
• Biocatalysis in development of green pharmaceutical processes.

  Tao J, Xu JH. Tao J, et al. Curr Opin Chem Biol. 2009 Feb;13(1):43-50. doi: 10.1016/j.cbpa.2009.01.018. Epub 2009 Mar 4. Curr Opin Chem Biol. 2009. PMID: 19264533 Review.
• Computational tools for designing and engineering biocatalysts.

  Damborsky J, Brezovsky J. Damborsky J, et al. Curr Opin Chem Biol. 2009 Feb;13(1):26-34. doi: 10.1016/j.cbpa.2009.02.021. Epub 2009 Mar 16. Curr Opin Chem Biol. 2009. PMID: 19297237 Review.