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. 2009 Mar;13(3):317-22.

First molecular epidemiological study of tuberculosis in Benin

D Affolabi  1 , G Anyo, F Faïhun, N Sanoussi, I C Shamputa, L Rigouts, L Kestens, S Anagonou, F Portaels
Affiliations
  • PMID: 19275790

First molecular epidemiological study of tuberculosis in Benin

D Affolabi et al. Int J Tuberc Lung Dis. 2009 Mar.

Abstract

Objectives: To assess the diversity of Mycobacterium tuberculosis strains in Cotonou, Benin, and the risk factors associated with clustering.

Methods: We analysed one sputum sample from 194 consecutive new pulmonary tuberculosis (TB) cases using two genotyping methods: spoligotyping and the 12 loci mycobacterial interspersed repetitive unit-variable number of tandem repeats (MIRU-VNTR). The data obtained were compared to the SpolDB4.0 database.

Results: We have found that spoligotype 61, highly predominant in West Africa, was also the most prevalent strain in Cotonou. We observed that the Beijing family represented 10.3% of strains and was associated with resistance to streptomycin. We also confirmed that combining spoligotyping and MIRU-VNTR provided a higher discriminatory power than the two techniques used individually.

Conclusion: Spoligotype 61 and Beijing genotype are the most prevalent genotypes of M. tuberculosis in Cotonou.

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