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. 2008:2008:389394.
doi: 10.1155/2008/389394. Epub 2009 Feb 5.

Esophageal carcinoma histology affects perioperative morbidity following open esophagogastrectomy

Charles E Woodall  1 , Ryan Duvall, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
Affiliations

Esophageal carcinoma histology affects perioperative morbidity following open esophagogastrectomy

Charles E Woodall et al. J Oncol. 2008.

Abstract

Background. Esophagectomy for esophageal cancer is being practiced routinely with favorable results at many centers. We sought to determine if tumor histology is a powerful surrogate marker for perioperative morbidity. Methods. Seventy three consecutive patients managed operatively were reviewed from our prospectively maintained database. Results. Adenocarcinoma (AC) was present in 52 (71%) and squamous cell (SCC) in 21 (29%). The use of neoadjuvant therapy was similar for the AC (34.62%) and SCC (42.86%) groups. The SCC group had a higher incidence of prior pulmonary disease than the AC group (23.8% versus 5.8%, resp.; P = .03). SCC patients were more likely to have a prolonged ICU stay than AC patients (P = .004) despite similar complication rates, EBL, and prognostic nutritional index. The SCC group did, however, experience higher grades of complications (P = .0053). Conclusions. Presence of SCC was the single best predictor of prolonged ICU stay and more severe complications as defined by this study. Only a past history of pulmonary disease was different between the two histologic subgroups.

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