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Review
. 2008:2008:715769.
doi: 10.1155/2008/715769. Epub 2009 Mar 5.

Passenger lymphocyte syndrome and liver transplantation

Affiliations
Review

Passenger lymphocyte syndrome and liver transplantation

Maxime Audet et al. Clin Dev Immunol. 2008.

Abstract

The authors reviewed the passenger lymphocyte syndrome (PLS) that has appeared after transplantation. The definition, mechanism, serological, clinical features, and treatment for PLS after solid organ transplantation, especially liver transplantation, are described. The PLS refers to the clinical phenomenon of alloimmune hemolysis resulting from the adoptive transfer of viable lymphocytes from donor during solid organ or hematopoietic stem cell transplant. Sometimes, it is very severe and may cause "unexplained" hemolysis during the postoperative period. The authors reviewed literature about the PLS in liver transplantation.

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References

    1. Yazer MH, Triulzi DJ. Immune hemolysis following ABO-mismatched stem cell or solid organ transplantation. Current Opinion in Hematology. 2007;14(6):664–670. - PubMed
    1. Sternberg AJ, Lee G, Croxton T, et al. Severe hemolysis after minor ABO unmatched kidney transplant—a non-secrector transplanted from a donor with high anti-A titre. Transfusion Medicine. 2000;10(1):87–89. - PubMed
    1. Sokol RJ, Stamps R, Booker DJ, et al. Posttransplant immune-mediated hemolysis. Transfusion. 2002;42(2):198–204. - PubMed
    1. Shortt J, Westall GP, Roxby D, et al. A ‘dangerous’ group O donor: severe hemolysis in all recipients of organs from a donor with multiple red cell alloantibodies. American Journal of Transplantation. 2008;8(3):711–714. - PubMed
    1. Seltsam A, Hell A, Heymann G, Salama A. Donor-derived alloantibodies and passenger lymphocyte syndrome in two of four patients who received different organs from the same donor. Transfusion. 2001;41(3):365–370. - PubMed

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