Comment
doi: 10.1016/j.str.2009.02.004.
Communication breakdown: protein dynamics and drug design
- PMID: 19278644
- DOI: 10.1016/j.str.2009.02.004
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Comment
Communication breakdown: protein dynamics and drug design
Structure.
.
Free article
Abstract
Mauldin et al. (2009) use NMR to show that drug binding can break up collective protein motions necessary for function. We discuss their findings in the context of drug discovery in pharmaceutical research.
Comment on
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Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state.Structure. 2009 Mar 11;17(3):386-94. doi: 10.1016/j.str.2009.01.005. Structure. 2009. PMID: 19278653 Free PMC article.
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