Patterns of photoprotection following CDKN2A/p16 genetic test reporting and counseling

Abstract

Background: The impact of melanoma genetic testing and counseling on photoprotective behaviors is unknown.

Objective: To determine if genetic testing and counseling alter compliance with photoprotection recommendations.

Methods: Reported use of sunscreen, protective clothing, and sun avoidance by 59 members of CDKN2A/p16-mutation positive pedigrees was assessed as a function of mutation status and melanoma history, before, immediately after, and 1 month following test reporting.

Results: Intentions to practice all photoprotective behaviors increased in all participant groups (P < .0001). At 1 month, 33% of participants reported the adoption of a new photoprotective behavior. Subpopulation analyses identified different patterns of change in photoprotection relative to baseline (P < .005), with no net decline in any group.

Limitations: This initial study of CDKN2A/p16 families is small and awaits replication in a larger sample.

Conclusion: Melanoma genetic testing and counseling enhanced intentions to implement photoprotective strategies and did not result in reduced compliance in the CDKN2A/p16-subpopulation.