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. 2009 Jun;32(6):1020-2.
doi: 10.2337/dc08-1925. Epub 2009 Mar 11.

Validation of continuous glucose monitoring in children and adolescents with cystic fibrosis: a prospective cohort study

Stephen M P O'Riordan  1 , Peter Hindmarsh, Nathan R Hill, David R Matthews, Sherly George, Peter Greally, Gerard Canny, Dubhfeasa Slattery, Nuala Murphy, Edna Roche, Colm Costigan, Hilary Hoey
Affiliations

Validation of continuous glucose monitoring in children and adolescents with cystic fibrosis: a prospective cohort study

Stephen M P O'Riordan et al. Diabetes Care. 2009 Jun.

Abstract

Objective: To validate continuous glucose monitoring (CGM) in children and adolescents with cystic fibrosis.

Research design and methods: Paired oral glucose tolerance tests (OGTTs) and CGM monitoring was undertaken in 102 children and adolescents with cystic fibrosis (age 9.5-19.0 years) at baseline (CGM1) and after 12 months (CGM2). CGM validity was assessed by reliability, reproducibility, and repeatability.

Results: CGM was reliable with a Bland-Altman agreement between CGM and OGTT of 0.81 mmol/l (95% CI for bias +/- 2.90 mmol/l) and good correlation between the two (r = 0.74-0.9; P < 0.01). CGM was reproducible with no significant differences in the coefficient of variation of the CGM assessment between visits and repeatable with a mean difference between CGM1 and CGM2 of 0.09 mmol/l (95% CI for difference +/- 0.46 mmol/l) and a discriminant ratio of 13.0 and 15.1, respectively.

Conclusions: In this cohort of children and adolescents with cystic fibrosis, CGM performed on two occasions over a 12-month period was reliable, reproducible, and repeatable.

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References

    1. Moran A: Diagnosis, screening, and management of cystic fibrosis-related diabetes. Curr Diab Rep 2002; 2: 111– 115 - PubMed
    1. Lanng ST, Nerup B, Koch JC: Influence of the development of diabetes mellitus on clinical status in patients with cystic fibrosis. Eur J Pediatr 1992; 151: 684– 687 - PubMed
    1. Finkelstein SM, Wielinski CL, Elliott GR, Warwick WJ, Barbosa J, Wu SC, Klein DJ: Diabetes mellitus associated with cystic fibrosis. J Pediatr 1988; 112: 373– 377 - PubMed
    1. Lanng S, Thorsteinsson B, Nerup J, Koch C: Diabetes mellitus in cystic fibrosis: effect of insulin therapy on lung function and infections. Acta Paediatr 1994; 83: 849– 853 - PubMed
    1. Dobson L, Hattersley AT, Tiley S, Elworthy S, Oades PJ, Sheldon CD: Clinical improvement in cystic fibrosis with early insulin treatment. Arch Dis Child 2002; 87: 430– 431 - PMC - PubMed

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